Podowart is a prescription topical medication primarily used to treat skin warts. The main active ingredient is podophyllum resin (20% w/v), which is made from the roots of the American mandrake and has been used to remove warts since at least the 1820s. Podowart also includes benzoin (10% w/v), which is a gum resin from the trunks of trees in the Styrax family, and aloe vera (2% w/v), which is a plant similar to a cactus that grows in hot climates and is generally used to alleviate sunburn.